Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of circulating inflammatory proteins as potential drug targets for sepsis through Mendelian randomization and colocalization analyses.

Medicine - 31 Oct 2025

Wan Fang, Shen Jie, Tang Jichun

Abstract excerpt

Sepsis is a complex disease with limited therapeutics. We conducted a 2-sample Mendelian randomization (MR) analysis to identify circulating inflammatory proteins as potential drug targets for sepsis. Protein quantitative trait loci (pQTLs) at cis-region for 448 circulating inflammatory proteins were obtained from the UK biobank pharma proteomics project (UKB-PPP) (N = 54219), and summary-level genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to APOE gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Sepsis

Source

Open in PubMed Open full text

Identifiers

PMID: 41261649
DOI: 10.1097/MD.0000000000045444
PMCID: PMC12582709

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of circulating inflammatory proteins as potential drug targets for sepsis through Mendelian randomization and colocalization analyses.PMID 41261649Read ↗

Using Mendelian randomization provides genetic insights into potential targets for sepsis treatmentSemantic proximity Read ↗

Therapeutic Targets for Sepsis: Multicenter Proteome-Wide Analyses and Experimental ValidationSemantic proximity Read ↗

Causal association of immune effector proteins with sepsis: A Mendelian randomization study.Semantic proximity Read ↗

Genetic association of lipids and lipid-lowering drugs with sepsis: a Mendelian randomization and mediation analysisSemantic proximity Read ↗

Circulating inflammatory cytokines and the risk of sepsis: a bidirectional mendelian randomization analysis.Semantic proximity Read ↗

Genetically predicted the causal association between circulating inflammatory proteins and sepsisSemantic proximity Read ↗

Enhancing insight into ferroptosis mechanisms in sepsis: A genomic and pharmacological approach integrating single-cell sequencing and Mendelian randomization.Semantic proximity Read ↗

Human Genetic Analysis Reveals Circulating Alpha-1 Antitrypsin Level as a Protective Factor in SepsisSemantic proximity Read ↗

Identification and validation of potential genes for the diagnosis of sepsis by bioinformatics and 2-sample Mendelian randomization studySemantic proximity Read ↗

Bioinformatics-based screening of sepsis biomarkersSemantic proximity Read ↗

Identifying potential macrophage polarization-related causal genes in sepsis through multi-omics mendelian randomization analysis and experimental validationSemantic proximity Read ↗

Identification and analysis of immune-related risk genes associated with sepsis through RNA sequencing and single-cell localization techniquesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.