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Mitochondrial-related genome-wide Mendelian randomization identifies putatively causal genes in the pathogenesis of sepsis

10 Feb 2025

Abstract excerpt

BACKGROUND: The dysfunction of mitochondria has been associated with the development of sepsis, but the specific mitochondrial-related genes and their roles in sepsis have not been fully elucidated. We employed Mendelian randomization and colocalization analysis to investigate the association between mitochondrial-related genes and sepsis by integrating multi-omics data. METHODS: Summary-level data on...

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PMID: 39933430
DOI: 10.1016/j.surg.2025.109150

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