Article

Kidney failure alters parathyroid Pin1 phosphorylation and parathyroid hormone mRNA binding proteins leading to secondary hyperparathyroidism

2021-12-06

Abstract excerpt

Parathyroid hormone (PTH) regulates calcium metabolism and bone strength. Chronic kidney disease leads to secondary hyperparathyroidism (SHP) which increases morbidity and mortality. In experimental SHP, the increased PTH gene expression is due to enhanced PTH mRNA stability, mediated by changes in its interaction with stabilizing AUF1 and destabilizing KSRP. Pin1 isomerizes target proteins and leads to KSRP dep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1eefedc-3751-513a-a618-5c63c66b2264
DOI: 10.1101/2021.12.06.470227

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Kidney failure alters parathyroid Pin1 phosphorylation and parathyroid hormone mRNA binding proteins leading to secondary hyperparathyroidismDOI 10.1101/2021.12.06.470227Read

Post‐transcriptional mechanisms regulating parathyroid hormone gene expression in secondary hyperparathyroidismSemantic proximity Read

Pin1 and secondary hyperparathyroidism of chronic kidney disease: gene polymorphisms and protein levels.Semantic proximity Read

Phosphoproteomic Analysis Reveals Regulatory Mechanisms at the Kidney Filtration BarrierSemantic proximity Read

The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels.Semantic proximity Read

Noncanonical Sequences Involving NHERF1 Interaction with NPT2A Govern Hormone-Regulated Phosphate Transport: Binding Outside the Box.Semantic proximity Read

Phosphorylation of key podocyte proteins and the association with proteinuric kidney diseaseSemantic proximity Read

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injurySemantic proximity Read

Oncogenic Hijacking of the PIN1 Signaling NetworkSemantic proximity Read

Ablation of the Renal Tubular Gluconeogenic Enzyme PCK1 Drives AKI-to-CKD Transition by Negatively Regulating the TGF-β/Smad3 Signaling PathwaySemantic proximity Read

In vivo treatment with calcilytic of CaSR knock-in mice ameliorates renal phenotype reversing downregulation of the vasopressin-AQP2 pathway.Semantic proximity Read

Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney diseaseSemantic proximity Read

Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophySemantic proximity Read