Article

Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy

2021-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Patients with advanced chronic kidney disease (CKD) often present with skeletal abnormalities; a condition known as renal osteodystrophy (ROD). While Tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 are recognized to be critical for bone mineralization, their role in the etiology of ROD is unclear. To address this, ROD was induced in both wild-type and Phospho1 knockout (P1KO) mice u...

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Literature Corpus work: 91b20b78-3bdf-5633-8987-1c719eec28ae
DOI: 10.1101/2021.08.06.455411

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