Article
Pin1 and secondary hyperparathyroidism of chronic kidney disease: gene polymorphisms and protein levels.
Renal failure - 1 Nov 2017
Zhao Yu, Zhang Li-Li, Ding Fa-Xian, Cao Ping, Qi Yuan-Yuan, Wang Jing
Abstract excerpt
BACKGROUND: Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is a key regulator of PTH mRNA stability. Secondary hyperparathyroidism (SHPT), which is characterized by elevated serum PTH levels, is a common complication of CKD. We investigated the possible associations between CKD with SHPT (CKD SHPT) and single-nucleotide polymorphisms of the Pin1 gene and compared the levels of the Pin1 protein in...
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