Article
Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 2010
Giallourakis Cosmas C, Franklin Andrew, Guo Chunguang, Cheng Hwei-Ling, Yoon Hye Suk, Gallagher Michael, Perlot Thomas, Andzelm Milena, Murphy Andrew J, Macdonald Lynn E, Yancopoulos George D, Alt Frederick W
Abstract excerpt
Ig and T-cell receptor (TCR) variable-region gene exons are assembled from component variable (V), diversity (D) and joining (J) gene segments during early B and T cell development. The RAG1/2 endonuclease initiates V(D)J recombination by introducing DNA double-strand breaks at borders of the germ-line segments. In mice, the Ig heavy-chain (IgH) locus contains, from 5' to 3', several hundred V(H) gene segments,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.