Article

BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

2024-05-10

Abstract excerpt

<h4>Background</h4> Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack of effective targets, it is crucial to identify novel molecular targets that would increase RT efficacy. Here we demonstrate the role of BUB1 (cell cycle Ser/Thr kinase) in TNBC radioresistance and offer a novel strategy to...

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Literature Corpus work: f1aab72f-d74e-54eb-8f0d-66852174c3cc
DOI: 10.1101/2024.05.07.592812

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