Article

Genome Instability and Pressure on Non-Homologous end Joining drives Chemotherapy Resistance via a DNA Repair Crisis Switch in Triple Negative Breast Cancer.

2020-11-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Chemotherapy intensifies pressure on the DNA repair pathways that can lead to deregulation. There is an urgent clinical need to be able to track the emergence of chemotherapy resistance and tailor patient staging appropriately. This is especially evident in the triple negative breast cancer (TNBC) subtype, of which standard of care is chemotherapy with tumours d...

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Literature Corpus work: 308d7bda-1b85-5d38-91b7-f425cf4dd34a
DOI: 10.21203/rs.3.rs-103661/v1

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