Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis

25 Jul 2013

Abstract excerpt

BACKGROUND: The discovery of molecular markers associated with various breast cancer subtypes has greatly improved the treatment and outcome of breast cancer patients. Unfortunately, breast cancer cells acquire resistance to various therapies. Mounting evidence suggests that resistance is rooted in the deregulation of the G1 phase regulatory machinery. METHODS: To address whether deregulation of the G1 phase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Breast Cancer Therapies
Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23886499
DOI: 10.1186/1747-1028-8-10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosisPMID 23886499Read ↗

Downregulation of TMPRSS4 Enhances Triple-Negative Breast Cancer Cell Radiosensitivity Through Cell Cycle and Cell Apoptosis Process ImpairmentSemantic proximity Read ↗

Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell deathSemantic proximity Read ↗

Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncologySemantic proximity Read ↗

Molecular targets that sensitize cancer to radiation killing: From the bench to the bedsideSemantic proximity Read ↗

The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancerSemantic proximity Read ↗

The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibitionSemantic proximity Read ↗

RB in Breast Cancer: The Crossroads of Tumorigenesis and TreatmentSemantic proximity Read ↗

Molecular Pathways: CDK4 Inhibitors for Cancer TherapySemantic proximity Read ↗

BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancerSemantic proximity Read ↗

Comparative analyses of prolonged stress responses of breast carcinoma cells after hypofractionated irradiation <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Activated ERK Signaling Is One of the Major Hub Signals Related to the Acquisition of Radiotherapy-Resistant MDA-MB-231 Breast Cancer Cells.Semantic proximity Read ↗

BRCA1-associated complexes: new targets to overcome breast cancer radiation resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.