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Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents

20 Sept 2021

Abstract excerpt

There has been accumulating evidence for the clinical benefit of chemoradiation therapy (CRT), whereas mechanisms in CRT-recurrent clones derived from the primary tumor are still elusive. Herein, we identified an aberrant BUB1B/BUBR1 expression in CRT-recurrent clones in bladder cancer (BC) by comprehensive proteomic analysis. CRT-recurrent BC cells exhibited a cell-cycle-independent upregulation of BUB1B/BUBR1...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 34545188
DOI: 10.1038/s41388-021-02021-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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