Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Aberrant DNA Double-Strand Break Repair in Triple-Negative Breast Cancer with Alpha-Particle Emitter Radiolabeled Anti-EGFR Antibody

20 Jul 2013

Abstract excerpt

The higher potential efficacy of alpha-particle radiopharmaceutical therapy lies in the 3- to 8-fold greater relative biological effectiveness (RBE) of alpha particles relative to photon or beta-particle radiation. This greater RBE, however, also applies to normal tissue, thereby reducing the potential advantage of high RBE. As alpha particles typically cause DNA double-strand breaks (DSB), targeting tumors that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Radiation Therapy and Dosimetry
Share to Radiopharmaceutical Chemistry and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23873849
DOI: 10.1158/1535-7163.mct-13-0108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting Aberrant DNA Double-Strand Break Repair in Triple-Negative Breast Cancer with Alpha-Particle Emitter Radiolabeled Anti-EGFR AntibodyPMID 23873849Read ↗

Radiation therapy for triple-negative breast cancer: from molecular insights to clinical perspectives.Semantic proximity Read ↗

Silencing of XRCC4 increases radiosensitivity of triple-negative breast cancer cellsSemantic proximity Read ↗

BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancerSemantic proximity Read ↗

DNA repair targeting and radiotherapy: a focus on the therapeutic ratio.Semantic proximity Read ↗

Radiation-induced EGFR-signaling and control of DNA-damage repairSemantic proximity Read ↗

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells.Semantic proximity Read ↗

Growth and molecular interactions of the anti-EGFR antibody Cetuximab and the DNA cross-linking agent cisplatin in gefitinib-resistant MDA-MB-468 cells: New prospects in the treatment of triple-negative/basal-like breast cancerSemantic proximity Read ↗

Reversion of the ErbB malignant phenotype and the DNA damage response.Semantic proximity Read ↗

Targeting XRCC1 Deficiency in Breast Cancer for Personalized TherapySemantic proximity Read ↗

Enhanced radiosensitivity of NSCLC cells by transducer of erbB2.1 (TOB1) through modulation of the MAPK/ERK pathwaySemantic proximity Read ↗

Building radiation-resistant model in triple-negative breast cancer to screen radioresistance-related molecular markersSemantic proximity Read ↗

Enhanced Anti-Tumor Effects by Combination of Tucatinib and Radiation in HER2-Overexpressing Human Cancer Cell LinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.