Article

Probing the limits of cis-acting gene regulation using a model of allelic imbalance quantitative trait loci

2024-10-04

Abstract excerpt

Imbalance in gene expression between alleles is a hallmark of cis- acting expression quantitative trait loci (eQTLs) and several methods have been developed to exploit allelic imbalance to support the identification of eQTLs. Allelic imbalance is also of scientific and, potentially, clinical interest as it can erode the degree to which the effects of deleterious variants are buffered in a diploid organism and has...

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Literature Corpus work: f1a153c6-2b39-5746-b703-87bbefd65c2f
DOI: 10.1101/2024.10.03.616423

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