Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leveraging allelic imbalance to refine fine-mapping for eQTL studies.

PLoS genetics - 1 Dec 2019

Zou Jennifer, Hormozdiari Farhad, Jew Brandon, Castel Stephane E, Lappalainen Tuuli, Ernst Jason, Sul Jae Hoon, Eskin Eleazar

Abstract excerpt

Many disease risk loci identified in genome-wide association studies are present in non-coding regions of the genome. Previous studies have found enrichment of expression quantitative trait loci (eQTLs) in disease risk loci, indicating that identifying causal variants for gene expression is important for elucidating the genetic basis of not only gene expression but also complex traits. However, detecting causal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allelic Imbalance
Share to Chromatin
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Linkage Disequilibrium

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 31834882
DOI: 10.1371/journal.pgen.1008481
PMCID: PMC6952111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leveraging allelic imbalance to refine fine-mapping for eQTL studies.PMID 31834882Read ↗

Leveraging allele-specific expression to refine fine-mapping for eQTL studiesSemantic proximity Read ↗

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL data.Semantic proximity Read ↗

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL dataSemantic proximity Read ↗

Haplotype-aware modeling of <i>cis</i> -regulatory effects highlights the gaps remaining in eQTL dataSemantic proximity Read ↗

Predictive long-range allele-specific mapping of regulatory variants and target transcripts.Semantic proximity Read ↗

Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues.Semantic proximity Read ↗

TreeMap: a structured approach to fine mapping of eQTL variants.Semantic proximity Read ↗

Redefining tissue specificity of genetic regulation of gene expression in the presence of allelic heterogeneity.Semantic proximity Read ↗

A scalable unified framework of total and allele-specific counts for cis-QTL, fine-mapping, and prediction.Semantic proximity Read ↗

Cross-population joint analysis of eQTLs: fine mapping and functional annotation.Semantic proximity Read ↗

Probing the limits of cis-acting gene regulation using a model of allelic imbalance quantitative trait lociSemantic proximity Read ↗

Multi-tissue analyses of allele-specific chromatin accessibility nominate likely functional variants for type 2 diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.