Article
Statistical inference of allelic imbalance from transcriptome data.
Human mutation - 1 Jan 2011
Nothnagel Michael, Wolf Andreas, Herrmann Alexander, Szafranski Karol, Vater Inga, Brosch Mario, Huse Klaus, Siebert Reiner, Platzer Matthias, Hampe Jochen, Krawczak Michael
Abstract excerpt
Next-generation sequencing and the availability of high-density genotyping arrays have facilitated an analysis of somatic and meiotic mutations at unprecedented level, but drawing sensible conclusions about the functional relevance of the detected variants still remains a formidable challenge. In this context, the study of allelic imbalance in intermediate RNA phenotypes may prove a useful means to elucidate the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.