Article
Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation.
Molecular biology and evolution - 1 Sept 2009
Tung Jenny, Fédrigo Olivier, Haygood Ralph, Mukherjee Sayan, Wray Gregory A
Abstract excerpt
Variation in gene expression is an important contributor to phenotypic diversity within and between species. Although this variation often has a genetic component, identification of the genetic variants driving this relationship remains challenging. In particular, measurements of gene expression usually do not reveal whether the genetic basis for any observed variation lies in cis or in trans to the gene, a...
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