Article
Detection of allelic imbalance in gene expression using pyrosequencing.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Wang Hua, Elbein Steven C
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) are common in the human genome, with more than 11 million SNPs having frequencies greater than 1%. The challenge is to identify the minority of functional SNPs from the large number of SNPs that are expected to be silent. Whereas coding variants are unusual, and functional (nonsynonymous) coding SNPs likely rare, regulatory SNPs appear to be common. Traditional methods to...
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