Article

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL data

2022-03-01

Abstract excerpt

<title>Abstract</title> <p>Expression Quantitative Trait Loci (eQTLs) are critical to understanding the mechanisms underlying disease-associated genomic loci. Nearly all protein-coding genes in the human genome have been associated with one or more eQTLs. Here we introduce a multi-variant generalization of allelic Fold Change (aFC), aFC-n, to enable accurate quantification of the <italic>cis</italic>-regulatory e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6eae9738-f2ea-5295-9f83-13d575259efe
DOI: 10.21203/rs.3.rs-1304545/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL dataDOI 10.21203/rs.3.rs-1304545/v1Read

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL data.Semantic proximity Read

Haplotype-aware modeling of <i>cis</i> -regulatory effects highlights the gaps remaining in eQTL dataSemantic proximity Read

Genotype-based test in mapping cis-regulatory variants from allele-specific expression data.Semantic proximity Read

Local genetic effects on gene expression across 44 human tissuesSemantic proximity Read

A vast resource of allelic expression data spanning human tissues.Semantic proximity Read

Leveraging allele-specific expression to refine fine-mapping for eQTL studiesSemantic proximity Read

Identifying Genetic Regulatory Variants that Affect Transcription Factor ActivitySemantic proximity Read

Leveraging allelic imbalance to refine fine-mapping for eQTL studies.Semantic proximity Read

Transcription factor regulation of eQTL activity across individuals and tissuesSemantic proximity Read

A vast resource of allelic expression data spanning human tissuesSemantic proximity Read

Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change.Semantic proximity Read

Redefining tissue specificity of genetic regulation of gene expression in the presence of allelic heterogeneitySemantic proximity Read