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A nucleic acid labeling chemistry reveals surface DNA on exosomes

2025-11-19

Abstract excerpt

Chemical labeling of nucleic acids is essential to pinpoint the structure, localization, and function of RNA and DNA. Yet, reversible sequence-independent chemistries that can label native RNA and DNA remain poorly developed. Here we describe Reversible Uridine Nitrilium-mediated Addition (RUNA), a reversible covalent chemistry that selectively modifies uridine and thymidine residues via N3 deprotonation and reac...

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Identifiers and source

Literature Corpus work
f1a066fb-336d-5fa7-b0d8-0e5521bee88e
DOI
10.1101/2025.11.18.689134
Open publication

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A nucleic acid labeling chemistry reveals surface DNA on exosomesDOI 10.1101/2025.11.18.689134
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