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New insights into nucleic acid sensor AIM2: The potential benefit in targeted therapy for cancer

24 Jan 2024

Abstract excerpt

The AIM2 inflammasome represents a multifaceted oligomeric protein complex within the innate immune system, with the capacity to perceive double-stranded DNA (dsDNA) and engage in diverse physiological reactions and disease contexts, including cancer. While originally conceived as a discerning DNA sensor, AIM2 has demonstrated its capability to discern various nucleic acid variations, encompassing RNA and DNA-RNA...

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PMID: 38272334
DOI: 10.1016/j.phrs.2024.107079

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