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System genetics in the rat HXB/BXH family identifies <i>Tti2</i> as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose

2021-06-04

Abstract excerpt

Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases. The molecular relationships between neural stem cell activity, adult neurogenesis, and global metabolism are largely unknown. Here we applied unbiased systems genetic methods to quantify genetic covariation among adult neurogenesis and metabolic phenotypes i...

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Literature Corpus work
f19bc24b-46dd-5074-9d17-df80b81d967e
DOI
10.1101/2021.06.04.447058
Open publication

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System genetics in the rat HXB/BXH family identifies <i>Tti2</i> as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucoseDOI 10.1101/2021.06.04.447058
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