Article
Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose.
PLoS genetics - 1 Apr 2022
Senko Anna N, Overall Rupert W, Silhavy Jan, Mlejnek Petr, Malínská Hana, Hüttl Martina, Marková Irena, Fabel Klaus S, Lu Lu, Stuchlik Ales, Williams Robert W, Pravenec Michal, Kempermann Gerd
Abstract excerpt
Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases. The molecular relationships between neural stem cell activity, adult neurogenesis, and global metabolism are largely unknown. Here we applied unbiased systems genetics methods to quantify genetic covariation among adult neurogenesis and metabolic phenotypes...
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