Article

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

2019-12-11

Abstract excerpt

Background: Respiratory syncytial virus (RSV) subtypes, A and B, co-circulate in annual epidemics and alternate in dominance. We have shown that a subtype A RSV fusion (F) glycoprotein, stabilized in its prefusion conformation by DS-Cav1 mutations, is a promising RSV-vaccine immunogen, capable of boosting RSV-neutralizing titers in healthy adults. In both humans and vaccine-tested animals, neutralizing titers elic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1909717-43da-555e-b350-633360b97ea1
DOI: 10.20411/pai.v4i2.338

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype BDOI 10.20411/pai.v4i2.338Read

Flexible RSV prefusogenic fusion glycoprotein exposes multiple neutralizing epitopes that may collectively contribute to protective immunitySemantic proximity Read

Alternative conformations of a major antigenic site on RSV FSemantic proximity Read

Functional implications of respiratory syncytial virus F sequence variability: a comparative analysis using contemporary RSV isolatesSemantic proximity Read

Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.Semantic proximity Read

Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.Semantic proximity Read

Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens.Semantic proximity Read

Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B.Semantic proximity Read

Emergence of new antigenic epitopes in the glycoproteins of human respiratory syncytial virus collected from a US surveillance study, 2015–17Semantic proximity Read

Phylodynamics and molecular epidemiology of the respiratory syncytial virus fusion protein in China.Semantic proximity Read

A tale of two fusion proteins: understanding the metastability of human respiratory syncytial virus and metapneumovirus and implications for rational design of uncleaved prefusion-closed trimersSemantic proximity Read

Mutating a flexible region of the RSV F protein can stabilize the prefusion conformation.Semantic proximity Read

A multi-center study to determine genetic variations in the fusion gene of respiratory syncytial virus (RSV) from children <2 years of age in the U.S.Semantic proximity Read