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Article

Mutating a flexible region of the RSV F protein can stabilize the prefusion conformation.

Science (New York, N.Y.) - 27 Sept 2024

Liang Yu, Shao Shuai, Li Xin Yu, Zhao Zi Xin, Liu Ning, Liu Zhao Ming, Shen Fu Jie, Zhang Hao, Hou Jun Wei, Zhang Xue Feng, Jin Yu Qin, Du Li Fang, Li Xin, Zhang Jing, Su Ji Guo, Li Qi Ming

Abstract excerpt

The respiratory syncytial virus (RSV) fusion (F) glycoprotein is highly immunogenic in its prefusion (pre-F) conformation. However, the protein is unstable, and its conformation must be stabilized for it to function effectively as an immunogen in vaccines. We present a mutagenesis strategy to arrest the RSV F protein in its pre-F state by blocking localized changes in protein structure that accompany large-scale...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39325881
DOI: 10.1126/science.adp2362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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