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Functional implications of respiratory syncytial virus F sequence variability: a comparative analysis using contemporary RSV isolates

14 Apr 2025

Abstract excerpt

ABSTRACT Respiratory syncytial virus (RSV) remains a major global health issue. Therapeutic options are limited, but new prophylactics, all targeting the fusion (F) glycoprotein, were recently licensed. Although F sequence variation is limited, it is unclear if and how this variability translates to phenotypical differences. We analyzed full F sequences of 105 contemporary RSV isolates, gathered from children...

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PMID: 40227055
DOI: 10.1128/msphere.00860-24

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