Article
A multi-center study to determine genetic variations in the fusion gene of respiratory syncytial virus (RSV) from children <2 years of age in the U.S.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Sept 2022
Adhikari Bishnu, Hassan Ferdaus, Harrison Christopher J, Dien Bard Jennifer, Dunn Jim, Kehl Sue, Selvarangan Rangaraj
Abstract excerpt
The fusion (F) protein of respiratory syncytial virus (RSV) is the major target of immunoprophylactic monoclonal antibodies (mAbs) and vaccines. Recently reported mutations in F gene antigenic sites can vary among RSV types A and B. To further understand mutations in RSV F proteins, we performed subtyping and F gene sequencing on 400 RSV-positive respiratory samples collected at four pediatric hospitals within...
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