Article

A tale of two fusion proteins: understanding the metastability of human respiratory syncytial virus and metapneumovirus and implications for rational design of uncleaved prefusion-closed trimers

2024-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) cause human respiratory diseases and are major targets for vaccine development. In this study, we designed uncleaved prefusion-closed (UFC) trimers for the fusion (F) proteins of both viruses by examining mutations critical to F metastability. For RSV, we assessed four previous prefusion F designs, including the first and second...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 211f640e-e35a-58e2-8ed4-3c90826585ad
DOI: 10.1101/2024.03.07.583986

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A tale of two fusion proteins: understanding the metastability of human respiratory syncytial virus and metapneumovirus and implications for rational design of uncleaved prefusion-closed trimersDOI 10.1101/2024.03.07.583986Read

Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.Semantic proximity Read

A foldon-free prefusion F trimer vaccine for respiratory syncytial virus to reduce off-target immune responsesSemantic proximity Read

Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoproteinSemantic proximity Read

Flexible RSV prefusogenic fusion glycoprotein exposes multiple neutralizing epitopes that may collectively contribute to protective immunitySemantic proximity Read

Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.Semantic proximity Read

Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirusSemantic proximity Read

Alternative conformations of a major antigenic site on RSV FSemantic proximity Read

Computational protein engineering of a multivalent human metapneumovirus immunogen using the self-assembling RSV M2-1 tetrameric scaffoldSemantic proximity Read

Functional and antigenic constraints on the Nipah virus fusion proteinSemantic proximity Read

Structural Insight into Paramyxovirus and Pneumovirus Entry InhibitionSemantic proximity Read

A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion proteinSemantic proximity Read

Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimerSemantic proximity Read