Article
Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.
mAbs - 1 Jan 2000
Harshbarger Wayne, Abeyrathne Priyanka D, Tian Sai, Huang Ying, Chandramouli Sumana, Bottomley Matthew James, Malito Enrico
Abstract excerpt
Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infections resulting in medical intervention and hospitalizations during infancy and early childhood, and vaccination against RSV remains a public health priority. The RSV F glycoprotein is a major target of neutralizing antibodies, and the prefusion stabilized form of F (DS-Cav1) is under investigation as a vaccine...
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