Article
Dual Inhibitors Targeting G9a and GSK-3β: Translational Perspectives on Alzheimer’s Disease Treatment
2025-10-26
Abstract excerpt
Epigenetic dysregulation and abnormal kinase signaling are key factors in Alzheimer’s disease (AD), yet no existing treatment targets both. We introduce a dual-targeting strategy that inhibits the histone methyltransferase G9a and the serine/threonine kinase GSK-3β—two synergistic drivers of neurodegeneration—using a single CNS-penetrant small molecule. This report covers the rational design, synthesis, and precli...
Topics
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- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Histone Deacetylase Inhibitors Research
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Protein Degradation and Inhibitors
Identifiers and source
- Literature Corpus work
- 0bd86fc4-4c86-569d-9067-5480fee137b6
- DOI
- 10.1101/2025.10.24.684310