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Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception

8 May 2025

Abstract excerpt

How tumor microenvironment shapes lung adenocarcinoma (LUAD) precancer evolution remains poorly understood. Spatial immune profiling of 114 human LUAD and LUAD precursors reveals a progressive increase of adaptive response and a relative decrease of innate immune response as LUAD precursors progress. The immune evasion features align the immune response patterns at various stages. TIM-3-high features are enriched...

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PMID: 40345189
DOI: 10.1016/j.ccell.2025.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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