Article

A fine-grained cell type deconvolution of bulk transcriptome from single-cell RNA-seq data reveals myeloid cells heterogeneity in lung adenocarcinomas

2021-03-01

Abstract excerpt

<title>Abstract</title> <p>Background Tumor infiltrating myeloid cells (TIM) constitute a vital element of the tumor microenvironment. The cell-type heterogeneity of TIM has yet to be fully investigated. Methods We used a time saving approach to generate a single-cell reference matrix, allowing quantification of cell-type proportions and cell-type-specific gene abundances in bulk RNA-seq data. Results Two dist...

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Literature Corpus work: 32417cc7-bcd0-593a-be16-2127c4e9695a
DOI: 10.21203/rs.3.rs-261065/v1

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