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Article

Spatially resolved whole-transcriptomic profiling of EGFR-mutated lung adenocarcinomas stratified by PD-L1 expression.

Cellular oncology (Dordrecht, Netherlands) - 22 Dec 2025

Yu Chenxi, Shi Chenxi, Zhou Hao, Li Na, Ma Ruyi, Liu SongBai, Tang Zaixiang, Zhang Xianling, Lei Zhe, Qin Hualong

Abstract excerpt

PURPOSE: High programmed death-ligand 1 (PD-L1) expression is associated with unfavorable clinical outcomes in epidermal growth factor receptor (EGFR)-mutated lung adenocarcinomas (LUAD) patients treated with tyrosine kinase inhibitors (TKIs) or anti-PD-1/PD-L1 therapy, yet the underlying mechanisms are less explored. METHODS: Bulk RNA sequencing (RNA-seq) datasets were analyzed to investigate intertumoral...

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Source

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Identifiers

PMID: 41430030
DOI: 10.1007/s13402-025-01143-9
PMCID: PMC12722276

Genes

EGFR
DSP
CD276
HAVCR2
LGALS9C

Provenance

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