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Article

KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo.

Nature communications - 2 Jan 2024

Najumudeen Arafath K, Fey Sigrid K, Millett Laura M, Ford Catriona A, Gilroy Kathryn, Gunduz Nuray, Ridgway Rachel A, Anderson Eve, Strathdee Douglas, Clark William, Nixon Colin, Morton Jennifer P, Campbell Andrew D, Sansom Owen J

Abstract excerpt

Oncogenic KRAS mutations are well-described functionally and are known to drive tumorigenesis. Recent reports describe a significant prevalence of KRAS allelic imbalances or gene dosage changes in human cancers, including loss of the wild-type allele in KRAS mutant cancers. However, the role of wild-type KRAS in tumorigenesis and therapeutic response remains elusive. We report an in vivo murine model of...

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Share to Allelic Imbalance
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 38168062
DOI: 10.1038/s41467-023-44342-4
PMCID: PMC10762264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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