Article

Human Pluripotent Stem Cell Derived Organoids Reveal a Role for WNT Signaling in Dorsal-Ventral Patterning of the Hindgut

2024-03-06

Abstract excerpt

<h4>Summary</h4> The cloaca is a transient structure that forms in the terminal hindgut giving rise to the rectum dorsally and the urogenital sinus ventrally. Similarly, human hindgut cultures derived from human pluripotent stem cells generate human colonic organoids (HCOs) which also contain co-developing urothelial tissue. In this study, our goal was to identify pathways involved in cloacal patterning and apply...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f133da09-46ef-5b9e-8961-1d2ccbaff1c7
DOI: 10.1101/2024.03.04.583343

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Pluripotent Stem Cell Derived Organoids Reveal a Role for WNT Signaling in Dorsal-Ventral Patterning of the HindgutDOI 10.1101/2024.03.04.583343Read

Anal skin-like epithelium mediates colonic wound healingSemantic proximity Read

Mapping mesenchymal diversity in the developing human intestine and organoidsSemantic proximity Read

A Development-Inspired Niche for Homeostatic Human Mini-IntestinesSemantic proximity Read

An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestineSemantic proximity Read

Defining the molecular pathologies in cloaca malformation: similarities between mouse and humanSemantic proximity Read

Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma CellsSemantic proximity Read

Suspension-Based Human Esophagoids Recapitulate WNT2B-Dependent Regulation of Esophageal Basal ProgenitorsSemantic proximity Read

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohn’s diseaseSemantic proximity Read

Maturation of human intestinal epithelium from pluripotency <i>in vitro</i>Semantic proximity Read

Spatial organisation and homeostasis of epithelial lineages at the gastroesophageal junction is regulated by the divergent Wnt mucosal microenvironmentSemantic proximity Read

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In VivoSemantic proximity Read

<i>In vitro</i> and <i>in vivo</i> development of the human intestinal niche at single cell resolutionSemantic proximity Read