Article
Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2019
Meagher Jennifer L, Takata Matthew, Gonçalves-Carneiro Daniel, Keane Sarah C, Rebendenne Antoine, Ong Heley, Orr Victoria K, MacDonald Margaret R, Stuckey Jeanne A, Bieniasz Paul D, Smith Janet L
Abstract excerpt
Infection of animal cells by numerous viruses is detected and countered by a variety of means, including recognition of nonself nucleic acids. The zinc finger antiviral protein (ZAP) depletes cytoplasmic RNA that is recognized as foreign in mammalian cells by virtue of its elevated CG dinucleotide content compared with endogenous mRNAs. Here, we determined a crystal structure of a protein-RNA complex containing...
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