Article

Haplotype Analysis of the TRB Locus by TCRB Repertoire Sequencing

2018-09-07

Abstract excerpt

Polymorphism within the T cell receptor beta variable gene (TRBV) has been implicated in autoimmune disease and immuneCrelated adverse events (IRAEs) during immunotherapy. Previous efforts to evaluate TRBV polymorphism by whole genome sequencing (WGS) have been hampered by the repetitive nature of the TCRB locus. We present a novel longCamplicon TCRB repertoire sequencing approach to evaluate TRBV polymorphism fro...

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Literature Corpus work: f0e35127-ddf0-5b2f-8956-5d3cdc0d3a3d
DOI: 10.1101/406157

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