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Article

STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability

27 Nov 2018

Abstract excerpt

Abstract Given the integral role of stimulator of interferon genes (STING, TMEM173) in the innate immune response, its loss or impairment in cancer is thought to primarily affect antitumor immunity. Here we demonstrate a role for STING in the maintenance of cellular homeostasis through regulation of the cell cycle. Depletion of STING in human and murine cancer cells and tumors resulted in increased proliferation...

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Identifiers

PMID: 30482772
DOI: 10.1158/0008-5472.can-18-1972

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