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Article

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability

10 Oct 2019

Abstract excerpt

Chromosomal instability (CIN) is an intricate phenomenon that is often found in human cancer, characterized by persisting errors in chromosome segregation. This ongoing chromosome mis-segregation results in structural and numerical chromosomal abnormalities that have been widely described to promote tumor evolution. In addition to being a driver of tumor evolution, recent evidence demonstrates CIN to be the...

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PMID: 31658669
DOI: 10.3390/cells8101228

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