Article

Cross-biobank genetics of gamma-glutamyl transferase in East Asians identifies loci, shared cardiometabolic comorbidities, and precision risk stratification for type 2 diabetes

2026-08-12

Abstract excerpt

Gamma-glutamyl transferase (GGT) is a clinically used biomarker of hepatobiliary injury and alcohol exposure, yet accumulating evidence links higher GGT to systemic cardiometabolic and other comorbidities. Although large-scale GWAS have defined many GGT-associated loci in European-ancestry cohorts, the genetic architecture of GGT, its cross-trait liability, and the translational utility of GGT polygenic risk remai...

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Literature Corpus work: f0d02a3d-2a49-565d-9493-3e8b7e5951e0
DOI: 10.1186/s13578-026-01631-x

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