Article
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
Human molecular genetics - 15 Jan 2012
Middelberg Rita P, Benyamin Beben, de Moor Marleen H M, Warrington Nicole M, Gordon Scott, Henders Anjali K, Medland Sarah E, Nyholt Dale R, de Geus Eco J C, Hottenga Jouke J, Willemsen Gonneke, Beilin Lawrence J, Mori Trevor A, Wright Margaret J, Heath Andrew C, Madden Pamela A F, Boomsma Dorret I, Pennell Craig E, Montgomery Grant W, Martin Nicholas G, Whitfield John B
Abstract excerpt
Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10(-8); rs944002 in C14orf73 on chromosome 14, P = 4.7 × 10(-13);...
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