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Liver Enzyme Genetics and Health Conditions in East Asians: Genetic Architecture and Causal Insights.

The journal of gene medicine - 1 Sept 2025

Lin Ying-Ju, Yang Jai-Sing, Li Ju-Pi, Chiou Jian-Shiun, Liu Ting-Yuan, Lu Hsing-Fang, Chou Chen-Hsing, Liang Wen-Miin, Chou I-Ching, Lin Ting-Hsu, Liao Chiu-Chu, Huang Shao-Mei, Tsai Fuu-Jen

Abstract excerpt

BACKGROUND: Elevated serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are biomarkers of liver dysfunction and predictors of cirrhosis and liver cancer. While European-ancestry GWAS have identified hundreds of loci influencing these enzymes and driven drug discovery and personalized interventions, comparable genetic studies in Han Taiwanese and other East Asian populations remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40902826
DOI: 10.1002/jgm.70033

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