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Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes.

Communications biology - 3 Nov 2022

Lee Chia-Jung, Chen Ting-Huei, Lim Aylwin Ming Wee, Chang Chien-Ching, Sie Jia-Jyun, Chen Pei-Lung, Chang Su-Wei, Wu Shang-Jung, Hsu Chia-Lin, Hsieh Ai-Ru, Yang Wei-Shiung, Fann Cathy S J

Abstract excerpt

To explore the complex genetic architecture of common diseases and traits, we conducted comprehensive PheWAS of ten diseases and 34 quantitative traits in the community-based Taiwan Biobank (TWB). We identified 995 significantly associated loci with 135 novel loci specific to Taiwanese population. Further analyses highlighted the genetic pleiotropy of loci related to complex disease and associated quantitative...

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Identifiers

PMID: 36329257
DOI: 10.1038/s42003-022-04168-0
PMCID: PMC9633758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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