Article

Reversible blood-brain barrier opening utilizing the membrane active peptide melittin <i>in vitro</i> and <i>in vivo</i>

2021-02-10

Abstract excerpt

The blood-brain barrier (BBB) tightly controls entry of molecules and cells into the brain, restricting the delivery of therapeutics. Blood-brain barrier opening (BBBO) utilizes reversible disruption of cell-cell junctions between brain microvascular endothelial cells to enable transient entry into the brain. Development of BBBO techniques has been hindered by a lack of physiological models for in vitro study. He...

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Literature Corpus work: f0a8b5d3-50f9-55c8-873e-570eaead2d97
DOI: 10.1101/2021.02.09.430012

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