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Enhanced <i>in Vivo</i> Blood Brain Barrier Transcytosis of Macromolecular Cargo Using an Engineered pH-sensitive Mouse Transferrin Receptor Binding Nanobody

2023-04-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used to carry macromolecular cargos with variable efficiency. Transcytosis involves trafficking through acidified intracellular vesicles, but it is not known whether pH-dep...

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Literature Corpus work: fe6ed94c-bb23-516c-9977-bbfadf0d2cf4
DOI: 10.1101/2023.04.26.538462

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