Back to search

Article

Claudin-5 binder enhances focused ultrasound-mediated opening in an <i>in vitro</i> blood-brain barrier model

2021-08-02

Abstract excerpt

<h4>Rationale</h4> The blood-brain barrier (BBB) while functioning as a gatekeeper of the brain, impedes cerebral drug delivery. An emerging technology to overcome this limitation is focused ultrasound (FUS). When FUS interacts with intravenously injected microbubbles (FUS +MB ), the BBB opens, transiently allowing the access of therapeutic agents into the brain. However, the ultrasound parameters need to be tig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8c1e7750-693f-55a0-9d64-c2abd12ff6e9
DOI
10.1101/2021.08.01.454692
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Claudin-5 binder enhances focused ultrasound-mediated opening in an <i>in vitro</i> blood-brain barrier modelDOI 10.1101/2021.08.01.454692
A claudin5-binding peptide enhances the permeability of the blood-brain-barrierSemantic proximity
A patient-derived amyotrophic lateral sclerosis blood-brain barrier cell model reveals focused ultrasound-mediated anti-TDP-43 antibody deliverySemantic proximity
Comprehensive Assessment of Blood-Brain Barrier Opening and Sterile Inflammatory Response: Unraveling the Therapeutic WindowSemantic proximity
Alzheimer’s disease brain endothelial-like cells reveal differential drug transporter expression and modulation by potentially therapeutic focused ultrasoundSemantic proximity
A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodiesSemantic proximity
Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrierSemantic proximity
Ultrasound Enhanced Drug Delivery in Pediatric Neurosurgery: A New Therapeutic StrategySemantic proximity
Reversible blood-brain barrier opening utilizing the membrane active peptide melittin <i>in vitro</i> and <i>in vivo</i>Semantic proximity
Focused ultrasound increases gene delivery to deep brain structure following the administration of a recombinant adeno-associated virus in the cerebrospinal fluidSemantic proximity
Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery.Semantic proximity
Mechanically manipulate glymphatic transportation by ultrasound combined with microbubblesSemantic proximity
Neurobehavioral effects of focused ultrasound-mediated blood-brain barrier openingSemantic proximity
Select a neighboring publication to make it the new centre.