Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain-Penetrating Peptide Shuttles across the Blood–Brain Barrier and Extracellular-like Space

12 Dec 2023

Abstract excerpt

Systemic delivery of therapeutics into the brain is greatly impaired by multiple biological barriers─the blood–brain barrier (BBB) and the extracellular matrix (ECM) of the extracellular space. To address this problem, we developed a combinatorial approach to identify peptides that can shuttle and transport across both barriers. A cysteine-constrained heptapeptide M13 phage display library was iteratively panned...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to Monoclonal and Polyclonal Antibodies Research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38085066
DOI: 10.1021/acs.bioconjchem.3c00446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain-Penetrating Peptide Shuttles across the Blood–Brain Barrier and Extracellular-like SpacePMID 38085066Read ↗

Selection of phage‐displayed llama single‐domain antibodies that transmigrate across human blood‐brain barrier endotheliumSemantic proximity Read ↗

<i>In vivo</i> phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissuesSemantic proximity Read ↗

Characterization of brain transduction capability of a BBB-penetrant, peptide-displaying AAV vector in mice, rats and non-human primatesSemantic proximity Read ↗

In vivo phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissuesSemantic proximity Read ↗

Reversible blood-brain barrier opening utilizing the membrane active peptide melittin <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Exploring ITM2A as a new potential target for brain deliverySemantic proximity Read ↗

A claudin5-binding peptide enhances the permeability of the blood-brain-barrierSemantic proximity Read ↗

Human iPSC-derived brain endothelial microvessels in a multi-well format enable permeability screens of anti-inflammatory drugsSemantic proximity Read ↗

A Cost-Effective and Easy to Assemble 3D Human Microchannel-Blood-Brain Barrier Model and Its Application in Tumor MetastasisSemantic proximity Read ↗

Identification of cell type-specific cell-penetrating peptides through in vivo phage display leveraged by next generation sequencingSemantic proximity Read ↗

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling propertiesSemantic proximity Read ↗

Pathogen-inspired drug delivery to the central nervous systemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.