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Article

Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging.

Annual review of genetics - 23 Nov 2018

Zhang Lei, Vijg Jan

Abstract excerpt

DNA mutations as a consequence of errors during DNA damage repair, replication, or mitosis are the substrate for evolution. In multicellular organisms, mutations can occur in the germline and also in somatic tissues, where they are associated with cancer and other chronic diseases and possibly with aging. Recent advances in high-throughput sequencing have made it relatively easy to study germline de novo...

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Identifiers

PMID: 30212236
DOI: 10.1146/annurev-genet-120417-031501
PMCID: PMC6414224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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