Article

IRE1 activity regulates tumour and microenvironment cell lineage states while stratifying localised and metastatic prostate cancer

2025-03-15

Abstract excerpt

Prostate cancer (PCa) is an androgen receptor (AR) driven, high-incidence disease significantly contributing to cancer mortality. PCa is in need of better risk stratification at diagnosis and treatment outcomes in patients at high risk of metastasis. The unfolded protein response (UPR) is an AR-dependent process. However, the impact of the UPR transducer IRE1 on AR-dependent biology and treatment resistance has no...

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Literature Corpus work: f070e41c-a70f-56e0-8b89-188a3b52af1b
DOI: 10.1101/2025.03.13.643042

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