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Article

The functional implication of ATF6α in castration‐resistant prostate cancer cells

6 Jan 2023

Abstract excerpt

Stress in the endoplasmic reticulum (ER) may perturb proteostasis and activates the unfolded protein response (UPR). UPR activation is frequently observed in cancer cells and is believed to fuel cancer progression. Here, we report that one of the three UPR sensors, ATF6α, was associated with prostate cancer (PCa) development, while both genetic and pharmacological inhibition of ATF6α impaired the survival of...

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PMID: 36607288
DOI: 10.1096/fj.202201347r

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