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Targeting IRE1α reprograms the tumor microenvironment and enhances anti-tumor immunity in prostate cancer

15 Oct 2024

Abstract excerpt

Unfolded protein response (UPR) is a central stress response pathway that is hijacked by tumor cells for their survival. Here, we find that IRE1α signaling, one of the canonical UPR arms, is increased in prostate cancer (PCa) patient tumors. Genetic or small molecule inhibition of IRE1α in syngeneic mouse PCa models and an orthotopic model decreases tumor growth. IRE1α ablation in cancer cells potentiates...

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PMID: 39406723
DOI: 10.1038/s41467-024-53039-1

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