Article

HO-1 Nuclear Interactome Implications in Neuroendocrine Transdifferentiation in Prostate Cancer

2026-05-28

Abstract excerpt

Neuroendocrine prostate cancer (NEPC) is characterized by androgen receptor (AR) independence and poor response to conventional therapies, highlighting the need to unveil the molecular mechanisms behind NEPC. We previously showed that heme oxygenase 1 (HO-1, encoded by HMOX1) translocates to the nucleus exerting unexplored non-canonical functions. The present study delineates the nuclear interactome of HO-1 reveal...

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Literature Corpus work: 96ff3ca8-3420-5700-9280-5057d788209e
DOI: 10.20944/preprints202605.1959.v1

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